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WHO SHOULD NOT TAKE LEVITRA? difficulty with swallowingThe efficacy and safety of Cialis for once daily use for the treatment of ED, and the signs and symptoms of BPH, in patients with both conditions was evaluated in one placebo-controlled, multinational, double-blind, parallel-arm study which randomized 606 patients to receive either Cialis 2.5 mg, 5 mg, for once daily use or placebo. ED severity ranged from mild to severe and BPH severity ranged from moderate to severe. The full study population had a mean age of 63 years (range 45 to 83) and was 93% White, 4% Black, 3% other races; 16% were of Hispanic ethnicity. Patients with multiple co-morbid conditions such as diabetes mellitus, hypertension, and other cardiovascular disease were included.

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Animal Data — Animal reproduction studies showed no evidence of teratogenicity, embryotoxicity, or fetotoxicity when tadalafil was given to pregnant rats or mice at exposures up to 11 times the maximum recommended human dose (MRHD) of 20 mg/day during organogenesis. In one of two perinatal/postnatal developmental studies in rats, postnatal pup survival decreased following maternal exposure to tadalafil doses greater than 10 times the MRHD based on AUC. Signs of maternal toxicity occurred at doses greater than 16 times the MRHD based on AUC. Surviving offspring had normal development and reproductive performance. viagra free trial Viagra can be taken in 25 mg, 50 mg, and 100 mg doses. The typical starting dose is 50 mg, but your doctor can help you determine the best starting dose for you. Some patients must increase their dose to 100 mg to get the desired effect. For others, a lower dose is sufficient. Do not take Viagra with a meal high in fat, as it may reduce the effectiveness. swelling of the face, hands, feet, or lower legs

Published Online: April 7, 2014. doi:10.1001/jamainternmed.2014.594.

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